ANALYSIS OF MORPHOLOGICAL RESULTS OF KIDNEYS OF OFFSPRING OBTAINED UNDER CONDITIONS OF EXPERIMENTAL DIABETES

Authors

  • Mamadaliyeva Odinabonu Master’s student, Department of Morphology, Tashkent State Medical University, Tashkent, Uzbekistan.
  • Tilyabov Ikrom PhD, senior teacher Department of Human Anatomy and Clinical anatomy Tashkent medical academy Tashkent, Uzbekistan

Keywords:

morphology, morphometry, kidney, glomerulus, hyperglycemic nephropathies, atrophy, sclerosis, streptocasin diabetes mellitus.

Abstract

In the world, among endocrine diseases, diabetes mellitus and its consequences, kidney pathologies occupy the highest place in prevalence. According to the World Health Organization (WHO), "... studies in Australia, Europe, Central Asia, the Middle East and North America show that the prevalence of kidney diseases among the population is 10-45%, with an average level of 26% ..." [WHO data 2022, https://www.who.org]. At the same time, the development of modern diagnostic capabilities in the diagnosis of the disease in order to avoid a negative impact on people's lives, the occurrence of various conditions leading to an increase in the disease, leads to morphological and functional changes in the subtractive system.

References

1. Damasceno DC, Volpato GT, Sinzato YK, et al. Genotoxicity and fetal abnormality in streptozotocin-induced diabetic rats exposed to cigarette smoke prior to and during pregnancy. Experimental and Clinical Endocrinology and Diabetes. 2011;119(9):549–553.

2. Delaney CA, Dunger A, Di Matteo M, Cunningham JM, Green MH, Green IC (1995) Comparison of inhibition of glucose-stimulated insulin secretion in rat islets of Langerhans by streptozotocin and methyl and ethyl nitrosoureas and methanesulphonates. Lack of correlation with nitric oxide-releasing or O6-alkylating ability. Biochem Pharmacol 50:2015–2020

3. Damasceno DC, Kiss ACI, Sinzato YK, et al. Maternal-fetal outcome, lipid profile and oxidative stress of diabetic rats neonatally exposed to streptozotocin. Experimental and Clinical Endocrinology and Diabetes. 2011;119(7):408–413.

4. Delaney CA, Dunger A, Di Matteo M, Cunningham JM, Green MH, Green IC (1995) Comparison of inhibition of glucose-stimulated insulin secretion in rat islets of Langerhans by streptozotocin and methyl and ethyl nitrosoureas and methanesulphonates. Lack of correlation with nitric oxide-releasing or O6-alkylating ability. Biochem Pharmacol 50:2015–2020

5. Courtney M, Gjernes E, Druelle N, et al. The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells. PLoS Genetics. 2013;9(10)e1003934

6. Gross ML, Ritz E, Schoof A, et al. Renal damage in the SHR/N-cp type 2 diabetes model: comparison of an angiotensin-converting enzyme inhibitor and endothelin receptor blocker. Lab Invest 2003;83:1267–1277.

7. Lenzen S (2007) Alloxan and streptozotocin diabetes. In: Peschke E (ed) Endokrinologie III Vorträge im Rahmen des Projektes ‘Zeitstrukturen endokriner Systeme’. [Endocrinology III lectures within the ‘time structures of endocrine systems’ project framework]. Abhandlung der Sächs. Akad. Wiss., Math-naturwiss Klasse, Verlag der Sächsischen Akademie der Wissenschaften, Leipzig, commissioned by S. Hirzel Verlag, Stuttgart/Leipzig, pp 119–138

8. Rankin MM, Kushner JA. Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes. 2009;58:1365–1372.

9. Thyssen S, Arany E, Hill DJ. Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin. Endocrinology. 2006;147:2346–2356.

10. Wilson GL, Hartig PC, Patton NJ, LeDoux SP (1988) Mechanisms of nitrosourea-induced beta-cell damage. Activation of poly(ADP-ribose) synthetase and cellular distribution. Diabetes 37:213–216

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Published

2025-10-28

How to Cite

Mamadaliyeva Odinabonu, & Tilyabov Ikrom. (2025). ANALYSIS OF MORPHOLOGICAL RESULTS OF KIDNEYS OF OFFSPRING OBTAINED UNDER CONDITIONS OF EXPERIMENTAL DIABETES. INTEGRATION OF EDUCATION AND SCIENCE: GLOBAL CHALLENGES AND SOLUTIONS, 1(1), 393–398. Retrieved from https://worldconferences.us/index.php/iesg/article/view/151