FROM TISSUE ARCHITECTURE TO HORMONAL REGULATION: AN INTEGRATIVE MULTIMODAL STUDY OF ENDOCRINE ORGAN ADAPTATION TO CHRONIC MYCOBACTERIAL INFLAMMATION IN RATS
Keywords:
endocrine glands, thyroid, adrenal, mycobacteria, morphometry, histochemistry, immunohistochemistry, hormonal profiling, artificial intelligence, age-dependent adaptation.Abstract
Chronic infection and the sustained inflammation that accompanies it affect several endocrine organs at the same time, yet most experimental studies examine a single gland or a single analytical level. As a result, the way in which the endocrine system as a whole re-organises itself under prolonged immune stress - and how this depends on age - remains insufficiently characterised. An integrated approach that follows the response from tissue architecture through cellular and molecular markers to hormonal output offers a more complete understanding of endocrine adaptation.
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