PHARMACEUTICAL PROSPECTS FOR DEVELOPING WATER-SOLUBLE GRANULES BASED ON ROSA CANINA L. AND ZIZIPHUS JUJUBA MILL. FRUITS
Keywords:
Rosa canina L., Ziziphus jujuba Mill., medicinal plant materials, water-soluble granules, pharmaceutical technology, phytochemical composition, formulation development, quality control.Abstract
The development of water-soluble pharmaceutical granules based on medicinal plant materials represents a promising direction in modern pharmaceutical technology. This study concept focuses on the formulation potential of Rosa canina L. (rosehip) and Ziziphus jujuba Mill. (jujube) fruits as complementary sources of biologically active compounds. Rosehip fruits are known for their ascorbic acid, phenolic compounds, carotenoids, and other phytochemicals, whereas jujube fruits contain sugars, polyphenols, polysaccharides, and additional constituents that may contribute to their nutritional and functional properties. Combining these plant materials in a granulated dosage form may provide a practical approach to improving product handling, dose uniformity, and preparation convenience. The principal objective is to identify the technological and physicochemical factors governing the development of stable, rapidly dispersible granules. Particular attention is given to the selection of extraction conditions, excipients, granulation methods, drying parameters, moisture content, and preservation of heat-sensitive constituents. The proposed formulation strategy provides a basis for further experimental investigation and the development of standardized plant-based pharmaceutical products.
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