Clinical and Pathogenetic Significance of Neurohumoral Disorders in Patients with Heart Failure and Metabolic Dysfunction-Associated Fatty Liver Disease
Abstract
Background. The coexistence of heart failure (HF) and metabolic dysfunction-associated steatotic liver disease (MASLD) represents an important clinical problem in modern cardiology and hepatology. The comorbid course of these conditions is determined by complex interactions between metabolic, hemodynamic, inflammatory, and neurohumoral mechanisms. Particular attention is focused on activation of the sympathetic nervous system and the natriuretic peptide system. Therefore, assessment of urinary NT-proBNP and norepinephrine may provide additional information for the comprehensive evaluation of neurohumoral activity in patients with combined cardiometabolic disorders.
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