MORPHOLOGICAL AND CLINICAL EFFECTS OF BLOOD STOP HEMOSTATIC AGENT ON UTERINE WOUND HEALING IN OBSTETRIC HEMORRHAGE
Keywords:
obstetric hemorrhage, Blood Stop, local hemostasis, myometrial regeneration, uterine scar, microcirculation, cesarean section.Abstract
Postpartum hemorrhage remains one of the leading causes of maternal morbidity and mortality worldwide, and the morphological mechanisms underlying the tissue-level action of local hemostatic agents remain insufficiently studied. This study presents a combined experimental-clinical evaluation of the local hemostatic agent Blood Stop, focusing on its influence on myometrial regeneration, microcirculatory recovery, and scar formation after uterine wound closure, alongside its clinical hemostatic efficacy in obstetric practice. The findings demonstrate that Blood Stop promotes more complete morphological and functional healing of the uterine scar compared with conventional local hemostatic agents, while providing favorable clinical outcomes in terms of hemostasis time, blood loss volume, and recurrence rate.
References
1. Кулаков В.И., Серов В.Н., Абубакирова А.М. и др. Пути снижения материнской смертности, обусловленной акушерскими кровотечениями // Акушерство и гинекология. — 2001. — № 1. — С. 3–4.
2. Kellie F.J., Wandabwa J.N., Mousa H.A., Weeks A.D. Mechanical and surgical interventions for treating primary postpartum haemorrhage // Cochrane Database of Systematic Reviews. — 2020. — Vol. 7, № 7. — CD013663. DOI: 10.1002/14651858.CD013663
3. WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage. — Geneva: World Health Organization, 2012. — ISBN 978-92-4-154850-2. https://www.who.int/publications/i/item/9789241548502
4. Cullifer R.M., Makai G., Pacis M., Huynh T. Topical hemostatic and tissue-sealing agents in gynecologic surgery // Current Opinion in Obstetrics and Gynecology. — 2020. — Vol. 32, № 4. — P. 285–291. DOI: 10.1097/GCO.0000000000000632
5. Yapar Eyi E.G., Engin-Üstün Y., Kaba M., Mollamahmutoğlu L. Ankaferd blood stopper in episiotomy repair // Clinical and Experimental Obstetrics & Gynecology. — 2013. — Vol. 40, № 1. — P. 141–143. PMID: 23724529
6. Адамян Л.В., Серов В.Н., Филиппов О.С., Артымук Н.В. и др. Профилактика, лечение и алгоритм ведения при акушерских кровотечениях: клинические рекомендации (протокол). — М., 2014. — 25 с.
7. Касимова А., Негмаджанов Б.Б., Раббимова Г.Т. Сравнительная оценка эффективности методов профилактики кровотечения в последовом и раннем послеродовом периодах // Журнал проблем биологии и медицины— 2014. — № 4.1(81).
