CLINICAL AND BIOCHEMICAL JUSTIFICATION OF CHANGES IN WOMEN OF REPRODUCTIVE AGE WITH POLYCYSTIC OVARY SYNDROME
Keywords:
Polycystic ovary syndrome, PCOS, reproductive age, hyperandrogenism, insulin resistance, hormonal imbalance, metabolic syndrome, infertilityAbstract
Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age and is characterized by a combination of reproductive, hormonal, and metabolic abnormalities. This study aims to justify the clinical and biochemical changes observed in women with PCOS. The findings demonstrate that clinical manifestations such as menstrual irregularities, infertility, and hyperandrogenism are closely associated with underlying biochemical disturbances, including elevated androgen levels, insulin resistance, and dyslipidemia. Hormonal imbalance, particularly an increased LH/FSH ratio and decreased sex hormone-binding globulin, plays a key role in disease progression. Insulin resistance is identified as a central pathogenic factor linking metabolic and reproductive dysfunctions. The study emphasizes the importance of comprehensive clinical and biochemical evaluation for early diagnosis and effective management of PCOS, as well as prevention of long-term complications such as type 2 diabetes and cardiovascular diseases.
References
1. Norman, R. J., Dewailly, D., Legro, R. S., & Hickey, T. E. (2007). Polycystic ovary syndrome. The Lancet, 370(9588), 685–697.
2. Goodarzi, M. O., Dumesic, D. A., Chazenbalk, G., & Azziz, R. (2011). Polycystic ovary syndrome: Etiology, pathogenesis and diagnosis. Nature Reviews Endocrinology, 7(4), 219–231.
3. Legro, R. S., Arslanian, S. A., Ehrmann, D. A., et al. (2013). Diagnosis and treatment of PCOS: An endocrine society guideline. The Journal of Clinical Endocrinology & Metabolism, 98(12), 4565–4592.
4. Fauser, B. C. J. M., Tarlatzis, B. C., Rebar, R. W., et al. (2012). Consensus on women’s health aspects of PCOS. Human Reproduction, 27(1), 14–24.
