MORPHOLOGICAL CHANGES IN THE SKIN WITH THE USE OF PACLITAXEL IN THE EXPERIMENT
Keywords:
Key words: cancer, carcinogen, DMBA, chemotherapy, sarcomas, application.Abstract
Abstract. Often, during cancer chemotherapy, the main source determining the prognosis of the patient's condition is the presence of skin damage. The spectrum of skin pathologies during chemotherapy associated with tumors is very wide. That is why we devoted our study to tumor diseases. The increase in the number of oncological diseases in recent decades requires the development of new drugs and methods of influencing tumor cells, and in some cases, tightening of chemotherapy regimens. Along with successes in the treatment of tumor diseases, toxicity of treatment is a huge problem.
References
1. Bahronov J.J. Comparative morphology of kidney and nephron structures in rats treated with paclitaxel and pomegranate seed oil for breast cancer, as well as after chemotherapy // A new day in medicine. – Bukhara, 2024, No. 2 (64), - P. 168-178.
2. Bahronov Juraat Jurakulovich. Morphological and biochemical changes in experimental white female rats with breast cancer treated with cisplatin chemotherapy // Problems of biology and medicine. - Samarkand, 2023, - No. 6 (150), - P. 338-343.
3. Bahronov J.J. Changes in morphological and biochemical parameters in renal nephrons in rats treated with paclitaxel // A new day in medicine. - Bukhara, 2023, - #10 (60), - B. 495-499.
4. Bakhranov, J. J., & Teshaev, Sh. J. (2020). Morphometric characteristics of frequent nephron cysts in norm and pri vozdeystvii antiseptic-stimulator dorogova fractsii 2 na fone chronicheskoy luchevoy disease. Problemy biology and medicine, (4), 138-140.
5. Bakhranov J. Comparative morphology of the structure of the kidney and nephrona krys pri intravenous vedenii cisplatin i per os masla kostichek granata 21 den i timalina 7 dney pri rake molochnoy zhelely // Jurnal meditsina i inovatsii. - Tashkent, 2024, - No. 1 (13), -S. 89-1011.
6. Jurat Bakhronov. Induction of malignant neoplasm of the mammary gland in rats using the carcinogen 7,12-dimethylbenz(а)аnthracene In The Experiment// American Journal of Medicine and Medical Sciences. -Саlifornia, 2024, №14 (5), -P.
7.BAKHRONOV, J. A. J., TESHAEV, S. J., & SHODIEVA, M. S. (2021). Morphometric characteristics of parts of rat kidney nephron in normal and under the influence of an antiseptician-facility 2 road stimulator on the background of chronic radiating disease. International Journal of Pharmaceutical Research (09752366), 13(1).
8. Jur'at J. Bakhromov, Morphofunctional features of the kidney exposed to various factors // Science Asia. - Thailand, 2022. - №2 (48), - P. 865-869.
9. Bakhronov Jur'at J, Use of immunomodulators in chemotherapy, morphological and biochemical changes in the kidneys // Journal of Survey in Fisheries Sciences. - Сanada, 2023, - №10(2S), - P. 3909-3912.