LONGITUDINAL STUDY OF COAGULATION CHANGES IN PEDIATRIC ITP PATIENTS
Keywords:
Idiopathic thrombocytopenic purpura, pediatric hematology, longitudinal study, coagulation changes, platelet function, bleeding risk, thrombocytopeniaAbstract
This study investigates longitudinal changes in coagulation parameters in children diagnosed with idiopathic thrombocytopenic purpura (ITP). Pediatric ITP is an autoimmune disorder characterized by isolated thrombocytopenia, leading to an increased risk of bleeding. While platelet counts remain the primary marker for disease monitoring, evaluating changes in coagulation parameters over time provides a more comprehensive understanding of hemostatic function and bleeding risk. This study follows pediatric ITP patients longitudinally, analyzing standard coagulation tests, platelet function, and advanced hemostatic markers to identify trends, predict complications, and inform individualized management strategies.
References
1. Bussel, J. B., & George, J. N. (2006). Idiopathic thrombocytopenic purpura: Diagnosis and management. New England Journal of Medicine, 354(3), 290– 301.
2. Neunert, C., Lim, W., Crowther, M., Cohen, A., Solberg, L., & Crowther, M. A. (2011). The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood, 117(16), 4190–4207.
3. Provan, D., Stasi, R., Newland, A. C., Blanchette, V., Bolton-Maggs, P., Bussel, J. B., … & Rodeghiero, F. (2010). International consensus report on the investigation and management of primary immune thrombocytopenia. Blood, 115(2), 168–186.
4. Blanchette, V., & Bussel, J. B. (2004). Pediatric thrombocytopenia: Pathophysiology and clinical management. Hematology/Oncology Clinics ofNorth America, 18(6), 1267–1285.
5. Cines, D. B., & Blanchette, V. S. (2002). Immune thrombocytopenic purpura. New England Journal of Medicine, 346(13), 995–1008.
6. Michelson, A. D. (2012). Platelets. 3rd Edition. Academic Press.
7. Alarcón, M., & Gutiérrez, J. (2015). Platelet activation markers in pediatric thrombocytopenia. Hematology Reports, 7(2), 5987.
8. McMillan, R. (2007). The pathogenesis of chronic immune thrombocytopenic purpura. Seminars in Hematology, 44(4), S3–S11.
9. Cooper, N., & Bussel, J. (2006). The pathogenesis of immune thrombocytopenic purpura. British Journal of Haematology, 133(4), 364–374.
10.Schiffer, C. A., & Bussel, J. B. (2004). Thrombocytopenia in children and adults: Diagnostic approaches. Hematology, 2004(1), 22–30.
