ANALYSIS OF THE DYNAMICS OF HEMOSTATIC SYSTEM INDICATORS IN PATIENTS WITH IMMUNE MICROTHROMBOVASCULITIS UNDERGOING ANTICOAGULANT THERAPY
Keywords:
immune microthrombovasculitis, anticoagulant therapy, hemostatic dynamics, vasculitis, thrombosis resolution, coagulation parameters, Behçet's disease, Kawasaki disease, eosinophilic granulomatosis with polyangiitisAbstract
Immune microthrombovasculitis represents a complex pathological condition characterized by immune-mediated inflammation and microthrombotic events within small vessels, often complicating systemic vasculitides such as Behçet's disease, Kawasaki disease, and eosinophilic granulomatosis with polyangiitis (EGPA). This study analyzes the dynamics of hemostatic system indicators in patients undergoing anticoagulant therapy, drawing from recent clinical cases and systematic reviews spanning 2023–2025. Through a synthesis of data from pediatric and adult cohorts, we evaluate changes in coagulation parameters, thrombus resolution, and clinical outcomes. Key findings indicate that anticoagulant regimens, including heparin and vitamin K antagonists, facilitate thrombus resolution within 1–4 months, with normalization of indicators like international normalized ratio (INR) and eosinophil counts. However, efficacy varies by vasculitis subtype, underscoring the need for tailored monitoring. This analysis highlights the high relevance of anticoagulant therapy in mitigating thrombotic risks while emphasizing the importance of integrated immunosuppressive approaches for optimal hemostatic stability.
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