THE IMPACT OF CHRONIC ENDOMETRITIS ON CHRONIC PELVIC PAIN AND INFERTILITY IN WOMEN: MODERN DIAGNOSTIC METHODS AND TREATMENT STRATEGIES
Keywords:
chronic endometritis, chronic pelvic pain, infertility, modern diagnostic methods, treatment strategies, endometrial receptivity, immunohistochemistry, hysteroscopy, microbiome, regenerative therapy.Abstract
Chronic endometritis (CE) is a persistent inflammation of the endometrium, often asymptomatic and associated with infertility, recurrent implantation failure, and chronic pelvic pain. This thesis explores the impact of CE on chronic pelvic pain and infertility in women, modern diagnostic methods (histopathological analysis, CD138 immunohistochemistry, hysteroscopy, and microbiological tests), and treatment strategies (antibiotics, probiotics, and regenerative approaches). Based on the analysis of scientific literature, CE is found in 10-60% of infertile women, reduces endometrial receptivity, and worsens pregnancy outcomes. The study emphasizes the role of early detection and treatment of CE in improving clinical outcomes. Additionally, the association of CE with chronic pelvic pain is explained by increased inflammatory mediators and immune disruptions, requiring differential diagnosis with endometriosis or other conditions. Modern research indicates that the epidemiology of CE is high among reproductive-age women, with risk factors including prolonged bleeding, intrauterine manipulations, and microbiome alterations. This thesis provides recommendations for managing CE in clinical practice and highlights the need for developing molecular diagnostics and personalized treatment in the future.
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