Clinical and pathogenetic course of pneumonia in young children with endotoxemia
Keywords:
Pneumonia, Endotoxemia, Early childhood, Clinico-pathogenetic features, Inflammatory response, Biomarkers, Pediatric infectious diseaseAbstract
Pneumonia remains one of the leading causes of morbidity and mortality among children of early age. The pathogenic mechanisms underlying the disease are complex and multifactorial, with endotoxemia playing a critical role in disease progression. Endotoxins derived from Gram-negative bacteria trigger systemic inflammatory responses, leading to immune dysregulation, tissue damage, and worsened clinical outcomes. This study aims to investigate the clinico-pathogenetic features of pneumonia in young children complicated by endotoxemia. Clinical, laboratory, and imaging data from patients aged 0 to 3 years were analyzed to assess the correlation between endotoxemia markers and disease severity. The findings demonstrate that elevated endotoxin levels are significantly associated with increased pneumonia severity and adverse clinical manifestations. Monitoring endotoxemia biomarkers and implementing targeted therapeutic interventions may improve prognosis and treatment efficacy in this vulnerable population. Further research is needed to optimize diagnostic and treatment strategies for pediatric pneumonia complicated by endotoxemia.
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