THE RELATIONSHIP BETWEEN GUT MICROBIOTA DYSBIOSIS AND PATHOMORPHOLOGICAL CHANGES IN THE DIGESTIVE SYSTEM MUCOSA IN METABOLIC SYNDROME
Keywords:
gut microbiota; Dysbiosis; Metabolic syndrome; Intestinal mucosa; Pathomorphology; Short-chain fatty acids; Endotoxemia; Barrier permeability; Inflammation; Microbial metabolitesAbstract
Metabolic syndrome (MetS) is a multifaceted disorder characterized by obesity, insulin resistance, dyslipidemia, and hypertension, often linked to gut microbiota dysbiosis and subsequent alterations in the intestinal barrier. This study investigates the relationships between gut microbiota disruption and pathomorphological changes in the mucous membrane of the digestive system among patients with MetS. Utilizing advanced sequencing and histological analyses, we demonstrate that dysbiosis, marked by reduced microbial diversity and shifts in bacterial taxa, correlates with increased intestinal permeability, mucosal inflammation, and epithelial damage. These findings highlight the role of microbial metabolites and endotoxemia in exacerbating MetS pathology, offering insights into potential microbiota-targeted interventions for improving gut barrier integrity and metabolic health.
References
1. Cani PD, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56(7):1761-1772.
2. Turnbaugh PJ, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027-1031.
3. Gurung M, et al. Role of gut microbiota in type 2 diabetes pathophysiology. EBioMedicine. 2020;51:102590.
4. Portincasa P, et al. Gut microbiota and short-chain fatty acids: implications in obesity and metabolic syndrome. Int J Mol Sci. 2022;23(11):6215.
5. David LA, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559-563.
6. Vrieze A, et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology. 2012;143(4):913-916.e7.
7. Ding S, et al. High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS One. 2010;5(8):e12191.
8. Clarke SF, et al. Gut microbiota: the neglected endocrine organ. Mol Endocrinol. 2014;28(8):1221-1238.
9. Fan Y, Pedersen O. Gut microbiota in human metabolic health and disease. Nat Rev Microbiol. 2021;19(1):55-71.
10. Aron-Wisnewsky J, et al. Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders. Nat Rev Gastroenterol Hepatol. 2020;17(5):279-297.
