PROSPECTS OF BIOLOGICALLY ACTIVE SUBSTANCES BASED ON AMINOHYDROXYBENZOIC ACIDS AND THIOUREA FRAGMENT
Keywords:
para-aminosalicylic acid, thiourea , structure, biologically active substance, molecule.Abstract
Thiourea derivatives have been widely studied and are used as the most important reagents for organic synthesis, as well as biologically active substances and drugs in medicine [1,2]. One of them is para-aminosalicylic acid, which is a pharmacological substance. Also, scientific research has been conducted on the fact that the compound formed with thiourea exhibits various properties. The article reviews the latest trends in the production and synthesis of biologically active substances . In addition, substances based on thiourea and para-aminosalicylic acid have been studied .
References
1. Mahdi JG Medicinal potential of willow: A chemical perspective of aspirin discovery //Journal of Saudi Chemical Society. - 2010. - T. 14. – no. 3. - S. 317-322.
2. Brel AK et al. Sodium and lithium salts of hydroxybenzamides and their biological activity // Proceedings of the Volgograd State Technical University. - 2014. - no. 7. - S. 63-66.
3. Brel AK, Lisina SV, Budaeva Yu.N. Derivatives of hydroxybenzoic acids and their salts: Synthesis and pharmacological activity // Journal of General Chemistry. - 2015. - T. 85. - No. 2. - S. 213-218.
4. Bahromov Kh.K., Niyazov LN Quantum-chemical calculation of a derivative of salicylic acid with pyrimidine //Universum: chemistry and biology. - 2020. - no. 3-2 (69).
5. Pan P. et al. Synthesis and Properties of Degradable Polyesters Based on a Lignin Derivative, 4-Hydroxybenzoic Acid //Journal of Polymers and the Environment. - 2024. - S. 1-13.
6. Niyazov LN, Haydarova HA Modern trends in the development and synthesis of biologically active substances based on thiourea and paraaminosalicylic acid // Scientific Journal of Applied and Medical Sciences Vol. 02 Issue: 05 2023. 179-181 p.
7. L.N. Niyazov , Haydarova H. A. Poluchenie i izuchenie svoystv proizvodnyx paraaminosalicylovoy kisloty s thiomochevinoy // Ministry of science and higher education of the Republic of Kazakhstan Yujno-Kazakhstanskiy university imeni M. Auezova 2023g . 46-47 str .
