AGE-RELATED MORPHOLOGICAL CHANGES IN ALCOHOLIC LIVER CIRRHOSIS: A PATHOMORPHOLOGICAL AND HISTOLOGICAL ANALYSIS IN UZBEKISTAN, 2020–2025
Keywords:
alcoholic liver cirrhosis, age-related changes, pathological anatomy, histology, fibrosis, steatosis, hepatocellular carcinoma, Uzbekistan, epidemiology, morphology.Abstract
Alcoholic liver cirrhosis (ALC) causes 1.48 million deaths yearly, with rising prevalence in younger groups (25–34 years) and age-specific morphological patterns. This study examines age-related pathomorphological and histological changes in ALC among Uzbeks from 2020–2025, focusing on steatosis, fibrosis, and hepatocellular carcinoma (HCC). Analyzing 150 biopsy/autopsy specimens with H&E, Masson’s trichrome, and METAVIR scoring, results show younger patients (25–34) with 80% microvesicular steatosis and rapid F3–F4 fibrosis (2–3 years), while older (50+) exhibit 65% nodular regeneration and 15% HCC. Statistical tests (Chi-square, ANOVA) confirm significant differences in fibrosis (p<0.01) and necroinflammation (p<0.05). Findings support age-tailored diagnostics and prevention, amid Uzbekistan's rising alcohol use (8.1 liters/capita by 2025), offering insights for resource-limited settings.
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