EKSPERIMENTAL OSTEOARTROZDA BO‘G‘IM YONDOSH CHO‘NTAKLARINING MORFOLOGIK XUSUSIYATLARI VA ULARNING DINAMIKASI
Keywords:
osteoartroz, eksperimental model, bo'g'im yondosh cho'ntaklar, sinoviyal bursa, morfologiya, gistologiya.Abstract
Eksperimental osteoartroz (OA) bo'g'im yondosh cho'ntaklarda sinoviyal giperplaziya, neovaskulyarizatsiya, fibroz va xondrotsit gipertrofiyasi kabi asosiy morfologik o'zgarishlarni namoyon etadi. Ushbu tadqiqot gistologik va immunogistokimyoviy usullar orqali bu o'zgarishlarni batafsil tahlil qiladi, ularning bo'g'im degeneratsiyasi, surunkali og'riq va funktsional buzilishlardagi rolini ochib beradi. Natijalar inson OA ga o'xshash progressiv jarayonlarni ko'rsatadi, ekstratsellyular matriks remodeling va ekopik kalsifikatsiya bilan kuchaygan, bu kasallik og'irligini oshiradi. Yondosh cho'ntaklar yallig'lanishi bo'g'im gomostaziga ta'sir qiladi va OA ni kuchaytiruvchi elementlar sifatida harakat qiladi. Terapevtik maqsadlar neovaskulyarizatsiya yo'llarini va fibrotik jarayonlarni inhibe qilishni o'z ichiga oladi. Ushbu yondashuv preklinik tadqiqotlar va klinik amaliyot uchun batafsil tuzum taqdim etadi.
References
1. Dudarić, L., Dumić-Čule, I., Divjak, E., Cengić, T., Brkljačić, B., & Ivanac, G. (2023). Bone remodeling in osteoarthritis: Biological and radiological aspects. Medicina, 59(9), 1613. https://doi.org/10.3390/medicina59091613
2. Fernández-Martín, S., González-Cantalapiedra, A., Permuy, M., García-González, M., López-Peña, M., & Muñoz, F. (2021). Histomorphometric quantitative evaluation of long-term risedronate use in a knee osteoarthritis rabbit model. Frontiers in Veterinary Science, 8, 669815. https://doi.org/10.3389/fvets.2021.669815
3. Gorkava, I. M., Malyuk, M. O., Kulida, M. A., Klymchuk, V. V., Onyshchenko, O. V., Gonchar, V. V., Kovalenko, D. O., & Tarnavskyi, D. V. (2025). Histological changes in the joint tissues of rabbits with gonarthrosis. Regulatory Mechanisms in Biosystems, 16(2), e25090. https://doi.org/10.15421/0225090
4. He, Y., Li, Z., Alexander, P. G., Ocasio-Nieves, B. D., Yocum, L., Lin, H., & Tuan, R. S. (2020). Pathogenesis of osteoarthritis: Risk factors, regulatory pathways in chondrocytes, and experimental models. Biology, 9(8), 194. https://doi.org/10.3390/biology9080194
5. Kennedy, M. S., Nicholson, H. D., & Woodley, S. J. (2022). The morphology of the subacromial and related shoulder bursae: An anatomical and histological study. Journal of Anatomy, 240(5), 941–958. https://doi.org/10.1111/joa.13603
6. Loeser, R. F., Goldring, S. R., Scanzello, C. R., & Goldring, M. B. (2012). Osteoarthritis: A disease of the joint as an organ. Arthritis & Rheumatism, 64(6), 1697–1707. https://doi.org/10.1002/art.34453
